Sickle Cell Anemia in Adults Research Paper Example | Topics and Well Written Essays - 1750 words

Sickle Cell Anemia in Adults - Research Paper Example The disease is autosomal recessive. The genetic defect is in the HbS gene (Meremikwu, 2009). HbS mutation arises from a mutation that substitutes thymine for adenine in the 6th codon of the gene of beta chain, GAG to GTG. This change leads to coding of valine instead of glutamate in the 6th position of Hb chain. This type of hemoglobin is known as HbS which polymerizes easily under certain circumstances and alters the morphology of RBCs. Homozygous disease is the most severe form (Meremikwu, 2009). Sickle cell disease is most common in individuals residing in   or originating from sub-Saharan Africa. It also affects individuals from Caribbean, Meditteranean, Asian and Middle-eastern origin. "About 60,000 people in the US[ and 10,000 in the UK suffer from the disease" (Meremikwu and Okomo, 2011). "Sickle cell disease (SCD), the most common inherited blood disorder in the United States, is caused by a mutation in the hemoglobin-beta gene found on chromosome 11" (Parsh, 2013).Accordin g to Aljiburi et al (2012), "Sickle cell disease (SCD) is the most common inherited blood disorder in England."Pathophysiology and Pathogenesis  Ã‚  Ã‚  Ã‚   The abnormality in sickle cell disease lies in the hemoglobin. The molecule is mutated and is known as HbS. When deoxygenated, the HbS molecules polymerize to form psuedocrystalline structures called tactoids. These distort the red cell membranes making them form a characteristic sickle cell appearance. Sickling of cells mainly occurs in regions of microvasculature where blood flow is sluggish. Sickled cells incre

Management Efficiency Impact on Performance within CocaCola Dissertation

Management Efficiency Impact on Performance within CocaCola - Dissertation Example Coca Cola has been awarded severally for its management and market status the world over. The company has employed different management theories in different countries of operation to suit the market and human resource requirements. Betsy Morris a CNN-Money correspondent reported in her feature on Coca Cola management noted that the company’s management style directly impacted on delivery and profits. The early 2000s saw the company slur but the recent years of good management have seen it rise again. The theories of change management have seen the company record all time high profits in the last two years. Research Strategy and Methodology The evaluation process will use two instruments, the interview and the survey, to collect information on the intended Coca Cola project. The interview will be carried out on the top management of the company to gauge the management style. The process should run in a scheduled time frame of fourteen (14) weeks. The interview method provides detailed information and can develop relationships among participants. The limitations of this method are that it takes large amounts of time, can be costly and participants may feel uncomfortable. It is also hard to get time with the top brass management for the interview. The interviews should therefore be conducted face to face, over the phone or internet video calls and through emails. The second activity is to design surveys to be filled in anonymously by the low and midlevel workers of the company in different states.